Journal of Toxicology – Clinical Toxicology 1996 42(5):485-489. Benefits of parenteral deferoxamine for acute iron poisoning. Journal of Toxicology – Clinical Toxicology 1996 34(5):491-497. Toxicity with iron: Injection 500mg: Diazepam: Mx convulsions, anxiety, agitation and hypertonia 2° to toxins, toxicity with organophosphates: Tablets 2mg, 5mg, 10mg injection (Diazemuls) 10mg/2ml rectal solution 2. Risks of parenteral deferoxamine for acute iron poisoning. Rose urine – classical sign but does not necessarily indicate effective chelation.Infection (Yersinia and mucormycosis grow avidly with the ferrioxamine complex).It should ideally be given before iron moves intracellularly and systemic toxicity develops. Continue the infusion until the patient is clinically stable and the serum iron 24 hours (6 hours is usually sufficient). Home Toxicology Library Antidote Desferrioxamine is an effective iron chelator that is used to treat systemic iron toxicity or prevent the development of systemic toxicity following acute iron overdose.The rate may be increased in life-threatening toxicity up to 40 mg/kg/hour if blood pressure allows.Commence IV infusion at an initial dose of 15 mg/kg/hour.The management of individual cases of overdose remains problematic due to uncertainty about indications for antidote. Reconstitute 500mg of powder with 5ml of sterile water and dilute in 100ml of 0.9% saline or 5% dextrose. Background: Iron poisoning is potentially serious, but mortality has fallen worldwide since implementation of pack size and packaging restrictions, and changes in iron use during pregnancy.Iron levels >90 micro mol/L or 500 microgram/dL at 4-6 hours post ingestion.Systemic iron toxicity: Severe gastroenteritis, shock, metabolic acidosis and altered GCS.To prevent unintentional iron poisoning: Store all iron-containing supplements and multivitamins out of reach and sight of children. Unfortunately, the antidote itself is toxic at high doses, so prevention of iron overdoses is especially important. Desferrioxamine is an effective iron chelator that is used to treat systemic iron toxicity or prevent the development of systemic toxicity following acute iron overdose. Fortunately, there is an antidote for iron poisoning and it can be given for serious cases.
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